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Submucous plexus Myenteric plexus. Intrinsic factor IF , also known as gastric intrinsic factor GIF , is a glycoprotein produced by the parietal cells of the stomach. Human Physiology: The Basis of Medicine 3rd ed. Journal of Clinical Pathology. In pernicious anemia , which is usually an autoimmune disease , autoantibodies directed against intrinsic factor or parietal cells themselves lead to an intrinsic factor deficiency, malabsorption of vitamin B 12 , and subsequent megaloblastic anemia.

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Vitamin B 12 is acid-sensitive and in binding to transcobalamin I it can safely pass through the acidic stomach to the duodenum.

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Journal of Clinical Pathology. In most countries, intramuscular injections of vitamin B 12 are used to treat pernicious anemia. From Wikipedia, the free encyclopedia.

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